Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo

Custom DOE used
Published on:
Authors: Arias-Alpizar, Gabriela; Kong, Li; Vlieg, Redmar C.; Rabe, Alexander; Papadopoulou, Panagiota; Meijer, Michael S.; Bonnet, Sylvestre; Vogel, Stefan; van Noort, John; Kros, Alexander & Campbell, Frederick
Abstract:

“Surface charge plays a fundamental role in determining the fate of a nanoparticle, and any encapsulated contents, in vivo. Herein, we describe, and visualise in real time, light-triggered switching of liposome surface charge, from neutral to cationic, in situ and in vivo (embryonic zebrafish). Prior to light activation, intravenously administered liposomes, composed of just two lipid reagents, freely circulate and successfully evade innate immune cells present in the fish. Upon in situ irradiation and surface charge switching, however, liposomes rapidly adsorb to, and are taken up by, endothelial cells and/or are phagocytosed by blood resident macrophages. Coupling complete external control of nanoparticle targeting together with the intracellular delivery of encapsulated (and membrane impermeable) cargos, these compositionally simple liposomes are proof that advanced nanoparticle function in vivo does not require increased design complexity but rather a thorough understanding of the fundamental nano-bio interactions involved.”

Open Access

Publication: Nature Communications
Issue/Year: Nature Communications, Volume 11; Number 1; 2020
DOI: 10.1038/s41467-020-17360-9
Link: https://doi.org/10.1038/s41467-020-17360-9

Related Papers

LETO / LETO-3 Spatial Light Modulators
Authors: Xin Zhang, Yanwen Hu, Haolin Lin, Hao Yin, Zhen Li, Shenhe Fu and Zhenqiang Chen

Flat lens–based subwavelength focusing and scanning enabled by Fourier translation

Applications: Beam Shaping / Beam Steering,Pulse Application / -Shaping
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Qu, Z., Wang, K., Feng, C., Wu, T., Zhang, Y., Zhao, X., & Wang, J. L.

Optofluidic sorting of microparticles using Airy beams

Applications: Beam Shaping / Beam Steering,Bessel-/ Airy Beam Generation,Optical Trapping /-Tweezers
GAEA / GAEA-2 Spatial Light Modulators
Authors:Ekaterina A. Savchenkova, Andrey S. Ovchinnikov, Vladislav G. Rodin, Rostislav S. Starikov, Nikolay N. Evtikhiev, Pavel A. Cheremkhin

Adaptive non-iterative histogram-based hologram quantization

Applications: Deep Learning / Neuronal Network,Digital-/ Computer Holography/ CGH
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Jixiang Wang, Xin Xu, Hong Ye, Xin Zhang, and Guohua Shi

Efficient generation of high-contrast Bessel light sheets: a flexible method for improved imaging

Applications: Beam Shaping / Beam Steering,Bessel-/ Airy Beam Generation,Imaging/ Image Processing,Microscopy
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Treerathat Chomchok, Pemika Hirankittiwong, Apichart Pattanaporkratana, Bussayamas Phettong, Natthawat Hongkanchanakul, Pongthep Prajongtat, Tyler R. Hatch, Dharmendra Pratap Singh, and Nattaporn Chattham

Rotation of liquid crystal microdroplets in the intensity minima of an optical vortex beam

Applications: Higher Order Modes / Optical Vortex / OAM,Optical Trapping /-Tweezers
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Adrián Garmendía-Martínez, Francisco M. Muñoz-Pérez, Walter D. Furlan, Vicente Ferrando & Juan A. Monsoriu

Bifocal diffractive lenses based on the aperiodic Kolakoski sequence

Applications: Adaptive Optics / Wavefront Control,Misc.: Speckle / Characterization / Metrology
LC 2012 Spatial Light Modulators
Authors:Pedro J. Aguilera-Rojas, Karin Alfaro-Bittner, Marcel G. Clerc, Manuel Díaz-Zúñiga, Amaru Moya, David Pinto-Ramos & René G. Rojas

Nonlinear wave propagation in a bistable optical chain with nonreciprocal coupling

Applications: Misc.: Speckle / Characterization / Metrology
LETO / LETO-3 Spatial Light Modulators
Authors:Zheng Yuan, Chenchen Zhang, Yuan Gao, Wenxiang Yan, Xian Long, Zhi-Cheng Ren, Xi-Lin Wang, Jianping Ding, and Hui-Tian Wang

Dual-curvilinear beam enabled tunable manipulation of high- and low-refractive-index particles

Applications: Higher Order Modes / Optical Vortex / OAM,Optical Trapping /-Tweezers
LC 2012 PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Jiaosheng Li, Yifei Chen, Tianyun Liu, Bo Wu & Qinnan Zhang

Single-pixel Fresnel incoherent correlation holography compressed imaging using a Trumpet network

Applications: Deep Learning / Neuronal Network,Digital-/ Computer Holography/ CGH,Imaging/ Image Processing
LETO / LETO-3 Spatial Light Modulators
Authors: Lukas T. Hiller, Jörg Wallaschek

Lensless projection of automotive light distributions using an advanced printer for volume holographic optical elements

Applications: Adaptive Optics / Wavefront Control,AR/VR/MR / Holographic Display
PLUTO / PLUTO-2 Spatial Light Modulators
Authors: I Komang Januariyasa, Francesco Reda, Fabio Borbone, Marcella Salvatore and Stefano L. Oscurato

Molding three-dimensional azopolymer microstructures with holographically structured light

Applications: Digital-/ Computer Holography/ CGH,Materials Processing / Optical Fabrication
LETO / LETO-3 Spatial Light Modulators
Authors:Yan Liu, Jianwei Qin, Yanbing Liu, Yuanan Liu, Xun Liu, Fangwei Ye, and Wei Li

Optical Fourier convolutional neural network with high efficiency in image classification

Applications: Deep Learning / Neuronal Network
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Juntao Hu, Wenjun Wei, Xinzhong Li, and Yixian Qian

Generation of polygonal non-diffracting beams via angular spectral phases

Applications: Beam Shaping / Beam Steering,Higher Order Modes / Optical Vortex / OAM,Microscopy
ERIS Spatial Light Modulators
Authors:Sumit Kumar Singh, Kenji Kinashi, Naoto Tsutsumi, Wataru Sakai, and Boaz Jessie Jackin

High-density polarization multiplexed holograms using azo-carbazole films for diverse applications

Applications: Digital-/ Computer Holography/ CGH,Polarization Generation
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:M. P. Morales Rodríguez, E. García Herrera, O. Magaña Loaiza, B. Perez-Garcia, F. Marroquín Gutíerrez, B. M. Rodríguez-Lara

Spatial light mode analogues of generalized quantum coherent states

Applications: Beam Shaping / Beam Steering,Higher Order Modes / Optical Vortex / OAM
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Kyriakos Skarsoulis, Konstantinos Makris, Christophe Moser, and Demetri Psaltis

Ptychographic imaging with a fiber endoscope via wavelength scanning

Applications: Deep Learning / Neuronal Network,Imaging/ Image Processing
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Gergely T. Iványi, Botond Nemes, Ilona Gróf, Tamás Fekete, Jana Kubacková, Zoltán Tomori, Gregor Bánó, Gaszton Vizsnyiczai, Lóránd Kelemen

Optically Actuated Soft Microrobot Family for Single-Cell Manipulation

Applications: Optical Trapping /-Tweezers
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Tong Zhou, Yuchao Hong, Jiantai Dou, Jiaqing Xu, Bo Li, Youyou Hu

Generation of multiple rotationally-symmetric power-exponent-phase vortex beams on a spatial arbitrary distribution by using holographic phase control techniques

Applications: Adaptive Optics / Wavefront Control,Higher Order Modes / Optical Vortex / OAM
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Wangting Zhou, Hui Xie, Kezhou Li, Zhiyuan Sun, Jiangshan He, Zhen Yuan, Xunbin Wei, Xueli Chen

Flexible depth-of-focus, depth-invariant resolution photoacoustic microscopy with Airy beam

Applications: Bessel-/ Airy Beam Generation,Microscopy,Pulse Application / -Shaping
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Shile Yang, Yuecheng Shen, Jiawei Luo, Zhengyang Wang, Daixuan Wu, Jiaming Liang, Zhiling Zhang, Dalong Qi, Yunhua Yao, Lianzhong Deng, Bin Zhang, Zhenrong Sun, and Shian Zhang

Neural network enabled fringe projection through scattering media

Applications: Deep Learning / Neuronal Network,Turbid-/ Opaque Media /Multi Scattering
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Siyu Gao, Xiaoyun Liu, Yonghao Chen, Jinyang Jiang, Ying Liu, Tengfei Chai and Yueqiu Jiang

Oceanic turbulence parameters recognition based on convolutional neural network

Applications: Adaptive Optics / Wavefront Control,Deep Learning / Neuronal Network,Optical Communication
LETO / LETO-3 Spatial Light Modulators
Authors:Manuel Hüpfel and Gerd Ulrich Nienhaus

Beam shaping in light-sheet microscopy: an experimental analysis

Applications: Beam Shaping / Beam Steering,Microscopy
PLUTO / PLUTO-2 Spatial Light Modulators
Authors:Bohnishikha Ghosh, Anat Daniel, Bernard Gorzkowski, Aleksandr Y. Bekshaev, Radek Lapkiewicz, and Konstantin Y. Bliokh

Canonical and Poynting currents in propagation and diffraction of structured light: tutorial

Applications: Higher Order Modes / Optical Vortex / OAM
LETO / LETO-3 Spatial Light Modulators
Authors:Manu Gopakumar, Gun-Yeal Lee, Suyeon Choi, Brian Chao, Yifan Peng, Jonghyun Kim & Gordon Wetzstein

Full-colour 3D holographic augmented-reality displays with metasurface waveguides

Applications: AR/VR/MR / Holographic Display,Deep Learning / Neuronal Network