Pixel super-resolution quantitative phase imaging based on modulation diversity

Abstract:
“Quantitative phase imaging with high resolution remains a long-term pursuit of many biomedical applications. However, the performance of coherent imaging systems is challenged by the intensity-only measurement mechanism and the sampling limit of the pixels. In this work, we introduce an imaging system that achieves pixel super-resolution quantitative phase imaging based on modulation diversity. A programmable phase-only spatial light modulator is used to generate various phase modulation patterns to the wavefront, providing data diversity for phase recovery at subpixel resolution. The system requires no mechanical displacements, enabling high-speed image acquisition, providing a competitive approach to high-throughput quantitative phase imaging applications.”