Author(s):

Liu, Xuan; Wan, Zhaoxiong; Zhang, Yuanwei & Liu, Yuwei

Abstract:

“Numerous drug delivery systems based on nanoparticles have been developed, such

as those used in BioNTech/Pfizer’s and Moderna’s Covid vaccines. Knowledge on mechanical

interactions between cells and nanoparticles is critical to advance the efficiency and safety

of these drug delivery systems. To quantitatively track the motion of cell (transparent) and

nanoparticles (nontransparent) with nanometer displacement sensitivity, we investigate a novel

imaging technology, optically computed phase microscopy (OCPM) that processes 3D spatial-

spectral data through optical computation. We demonstrate that OCPM has the capability to

image the motion of cells and magnetic nanoparticles that are mechanically excited by an external

magnetic field, quantitatively and in the en face plane.”

Link to Publications Page