Wide-field in situ multiplexed Raman imaging with superresolution

Author(s):

Houkai Chen and Xiaojing Wu and Yuquan Zhang and Yong Yang and Changjun Min and Siwei Zhu and Xiaocong Yuan and Qiaoliang Bao and Jing Bu

Abstract:

“Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surfaceenhanced Raman scattering (SERS) technique, wide-field Raman imaging is developed with a significant improvement in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-field multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields.”

Link to Publications Page

Publication: Photonics Research
Issue/Year/DOI: Photonics Research Volume 6, Issue 6 pp. 530-534
DOI: 10.1364/PRJ.6.000530

Micro-Dumbbells—A Versatile Tool for Optical Tweezers

Author(s):

Weronika Lamperska, Sławomir Drobczyński, Michał Nawrot, Piotr Wasylczyk, Jan Masajada

Abstract:

“Manipulation of micro- and nano-sized objects with optical tweezers is a well-established, albeit still evolving technique. While many objects can be trapped directly with focused laser beam(s), for some applications indirect manipulation with tweezers-operated tools is preferred. We introduce a simple, versatile micro-tool operated with holographic optical tweezers. The 40 µm long dumbbell-shaped tool, fabricated with two-photon laser 3D photolithography has two beads for efficient optical trapping and a probing spike on one end. We demonstrate fluids viscosity measurements and vibration detection as examples of possible applications.”

Link to Publications Page

Publication: Micromachines

Issue/Year/DOI: Micromachines Volume 9, Issue 6
DOI: 10.3390/mi9060277