Synthesis of light needles with tunable length and nearly constant irradiance.

Author(s):

Martínez-Herrero, Rosario and Maluenda, David and Juvells, Ignasi and Carnicer, Artur

Abstract:

“We introduce a new method for producing optical needles with tunable length and almost constant irradiance based on the evaluation of the on-axis power content of the light distribution at the focal area. According to theoretical considerations, we propose an adaptive modulating continuous function that presents a large derivative and a zero value jump at the entrance pupil of the focusing system. This distribution is displayed on liquid crystal devices using holographic techniques. In this way, a polarized input beam is shaped and subsequently focused using a high numerical aperture (NA) objective lens. As a result, needles with variable length and nearly constant irradiance are produced using conventional optics components. This procedure is experimentally demonstrated obtaining a 53λ-long and 0.8λ-wide needle.”

Link to Publications Page

Publication: Scientific Reports

Issue/Year/DOI: Scientific Reportsvolume 8, Article number: 2657 (2018)
DOI: 10.1038/s41598-018-21007-7

Investigation of albumin-derived perfluorocarbon-based capsules by holographic optical trapping

Author(s):

Jannis Köhler and Jegor Ruschke and Katja Bettina Ferenz and Cemal Esen and Michael Kirsch and Andreas Ostendorf

Abstract:

“Albumin-derived perfluorocarbon-based capsules are promising as artificial oxygen carriers with high solubility. However, these capsules have to be studied further to allow initial human clinical tests. The aim of this paper is to provide and characterize a holographic optical tweezer to enable contactless trapping and moving of individual capsules in an environment that mimics physiological (in vivo) conditions most effectively in order to learn more about the artificial oxygen carrier behavior in blood plasma without recourse to animal experiments. Therefore, the motion behavior of capsules in a ring shaped or vortex beam is analyzed and optimized on account of determination of the optical forces in radial and axial direction. In addition, due to the customization and generation of dynamic phase holograms, the optical tweezer is used for first investigations on the aggregation behavior of the capsules and a statistical evaluation of the bonding in dependency of different capsule sizes is performed. The results show that the optical tweezer is sufficient for studying individual perfluorocarbon-based capsules and provide information about the interaction of these capsules for future use as artificial oxygen carriers.”

Link to Publications Page

Publication: Biomed. Opt. Express

Issue/Year/DOI: Biomedical Optics Express Vol. 9,Issue 2, pp. 743-754(2018)

DOI: 10.1364/BOE.9.000743